butabarbital will lessen the level or influence of sulfamethoxazole by affecting hepatic enzyme CYP2C9/ten metabolism. Small/Significance Unfamiliar.butabarbital will decrease the level or effect of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.butabarbital will minimize the level or influence of cannabidiol by a